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Faculty/Staff Directory

Greta Ann Herin

DEPARTMENT: Biology Dept

POSITION: Associate Professor

DEPARTMENT: MA in Biomedicine

POSITION: Professor

LOCATION: Main Campus, Harrisonburg | SSC 026G

PHONE: (540) 432-4414

EMAIL: gretaann.herin@emu.edu

Greta Ann Herin has taught a wide variety of courses in general biology, biomedicine, and general education. Courses include: Advanced Human Anatomy; Faith, Science and Ethics; Human Anatomy and Physiology I and II; Neuropsychology; Advanced Neurobiology (undergraduate and masters-level students) ; Mammalian Physiology; Molecules, Genes, and Cells; Biological Explorations; and a Senior Seminar “The Elephant and the Rider”. She has also co-taught Concepts in Biology; a Senior Seminar “Form, Finitude and Faith”; a Senior Seminar “Origins”; and a Colloquium “Passion and Obsession”.

Greta Ann serves as a Pre-professional Health Sciences advisor.

She has dual Bachelors Degrees in Biochemistry and Psychology from Kansas State University and a Ph.D. in Neurobiology from the University of Pittsburgh School of Medicine. Her dissertation covers interactions among modulators of NMDA receptors, an important glutamate receptor in the brain. In addition Dr. Herin did a post-doctoral fellowship at the Max-Planck Institute for Brain Research in Frankfurt, Germany. There she studied metabotropic glutamate receptors.
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Education

Doctor of Philosophy
Program in Neurobiology (2003)
Department of Neurobiology
University of Pittsburgh School of Medicine, Pittsburgh, PA
Dissertation Advisor: Elias Aizenman, Ph.D.

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Bachelors of Sciences
Biochemistry (1994)
Psychology (1993)
Kansas State University, Manhattan, KS

Publications

Journal articles

  • Caldwell, J.H+., Herin, G.A+., Nagel, G., Bamberg, E., Scheschonka, A., Betz, H. (2008).
    Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of metabotropic glutamate receptor mGluR7.
    J Biol Chem. Sep 5;283(36):24300-7.
    + co-first authors
  • Zhang C.S., Bertaso F., Eulenburg V., Lerner-Natoli M., Herin G.A., Bauer L., Bockaert J., Fagni L., Betz H., Scheschonka A. (2008)
    Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol.
    J Neurosci. 2008 Aug 20;28(34):8604-14.
  • Mead, K., Dearworth, J., Grisham, W., Herin, G.A., Jarrad, H., Paul, C.A., Waldeck, R., Yates, J., Young, J. (2007)
    IFEL Tour: A description of the Introduction to FUN Electrophysiology Labs Workshop at Bowdon College July 27-30.
    Journal of Undergraduate Neuroscience.
  • Lu, Y., Epstein, P., Li, Y., Herin, G.A., Aizenman, E., and Rosenberg, P. (2004)
    Elevation of intracellular cAMP evokes activity-dependent release of adenosine in cultured rat forebrain neurons.
    European Journal of Neuroscience 19(10): 2669-81.
  • Legos J.J., McLaughlin, B., Skaper, S.D., Strijbos, P.J.M.L., Parsons, A.A., Aizenman, E., Barone, F.C., Herin, G.A., Erhardt, J.A. (2001)
    The selective p38 inhibitor SKB-239063 protects primary neurons from mild to moderate excitotoxic injury.
    European Journal of Pharmacology 447(1): 37-42.

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Other

  • Herin, G.A. (2003) Studies on Role of the N-terminal Domain of NR1 in the Redox Modulation of NR2A-Containing NMDA Receptors. Ph.D. Dissertation. University of Pittsburgh ETD

Scholarly Presentations and Abstracts

*Herin, G.A. (2015) The critical developmental stage of eye opening influences calcium dependent inactivation of calcium channels in striatal neurons in a region dependent manner. Invited Speaker, Department of Biology Seminar Series, James Madison University.

*Herin G.A. (2014) The role of calcium in neurophysiology as a signal and a feedback inhibitor: two cases. Keynote Speaker, Western Pennsylvania Undergraduate Psychology Conference.

  • Herin, G.A., Hannum, C.D., Vecchiarelli, H.A., Smucker, J. (2011) Metabotropic glutamate receptor 7a is inhibited by lead (Pb2+) in a concentration-dependent manner in Xenopus oocytes. Society for Neuroscience Meeting.
  • Herin, G.A. (2009) Modulation of Metabotropic Glutamate Receptor 7a in Xenopus Oocytes: Potentiation by Intracellular Calcium and Inhibition by Lead Chloride. Invited Speaker, Krasnow Institute for Advanced Studies, George Mason University
  • Herin G.A., Caldwell III, J.H., Scheschonka, A., Betz, H. (2006) Intracellular calcium modulates beta-gamma signaling of the metabotropic glutamate receptor 7. Federation for European Neuroscience Meeting.
  • Herin, G.A., Zheng, F., Le, P., and Aizenman, E. (2002) Evidence for an interaction between N-terminal redox sensitive cysteines and a polyamine modulatory site of the NR1/NR2A NMDA receptor. Society for Neuroscience Meeting.
  • Herin, G.A., Sinor, J.D., and Aizenman, E. (2001) Spermine inhibits DTT potentiation of responses mediated by cysteine mutant recombinant NMDA receptors. Society for Neuroscience Meeting.
  • Herin, G.A. and Aizenman, E. (2000) Ebselen oxidizes the NMDA receptor: A novel mechanism for neuroprotection. Society for Neuroscience Meeting.